Computational Biology Research Associate (Philpott lab)

The Philpott group in the Wellcome – MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/philpott), in collaboration with the Simons group at the Wellcome/CRUK Gurdon Institute (https://www.gurdon.cam.ac.uk/people/ben-simons/), are seeking a Research Associate in Computational Biology.

Mechanisms that lead to the establishment and maintenance of cell identity are paramount for organismal health. They also underpin successful cellular reprogramming for disease modelling and cell replacement therapies. Alongside experimental lab work using embryonic stem cells, cancer cells and Xenopus frog embryos, the Philpott lab, in collaboration with the Simons lab, makes use of computational approaches to study mechanisms of lineage fidelity and transcriptional reprogramming of cell fate during development and in disease. Current interests include the roles played by the epigenome and cofactors in regulating lineage transcription factor-mediated establishment and stabilisation of cell fate.

With experience in the application of computational methods, the role holder will have a key position in analysing single-cell and bulk genome-wide datasets across a range of projects and experimental model systems. This is a vital position in the Philpott group and the role holder will work closely with experimental colleagues to transform sequencing data into biologically meaningful information. Reflecting this central role in data analysis and integration, the role holder’s contributions will be acknowledged accordingly. There will also be the opportunity to carry independent research in close collaboration with experimental scientists in the lab.

Applicants should have a strong background in computational biology, and prior experience in the analysis of high-throughput genomic and transcriptomic data. Previous experience in the analysis of single-cell data would be an advantage. The applicant should have a PhD in a relevant subject, a sound understanding of molecular biology, and a strong publication track-record. As well as being able to work independently, the role requires strong communication skills and the ability to work in a dynamic multidisciplinary team environment.

The Philpott lab is located in the Cambridge Stem Cell Institute, which provides a stimulating environment that promotes collaborative and interdisciplinary research. Its postdoc association encourages scientific and social interactions and provides career development and teaching opportunities.

Informal enquiries can be directed to Dr Frances Connor (fac31@cam.ac.uk)