PhD: Deciphering morphogenesis of early human brain development in health and disease

Project Overview

A potential factor contributing to our cognitive superiority over other primates is not only our larger brain size, but also our brain’s morphology and organisation. To understand how these morphological parameters are modulated during early brain development is essential. Thus, the early development of the human brain is not well understood, and approaches allowing the study of these early developmental processes will shed light on what makes the human brain unique and has applications for the identification of developmental defects underpinning neurological disorders. We will use in vitro models of human cerebral organoids (derived from induced Pluripotent Stem Cells, iPSCs) to study neurogenesis and the formation of the human neuroepithelium.

In an interdisciplinary approach between the School of Biological and Behavioural Sciences (Palacios) and the School of Engineering and Materials Sciences (Gautrot), we will combine tissue and genetic engineering, cell biophysics, functional genetics by CRISPR, and computational modelling to study the molecular and cellular principles governing the early development of the human brain in health and disease. The outcome of the project will provide biological inspiration to the development of novel treatments and shine a light on neural mechanisms implicated in neurodevelopmental disorders (NDDs) such as autism.

Both laboratories have a genuine interest in learning how organs form and function, and by helping the development of disease treatments with such a knowledge. By combining organoids with bioengineering tools and theoretical modelling, the student will gain unprecedented insights into brain development both in health and in disease.

The successful candidate will have the opportunity to fine tune the project based on individual interests and skills.