The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease – see Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling.