The Quantitative Stem Cell Biology lab’s primary focus is understanding cell decision-making. Current areas of research include understanding regulatory mechanism regulating cell fate specification, cell cycle remodeling during cellular differentiation and the interplay between metabolism, cell cycle and cell fate.

A potential project is to understand the interplay between cell division and cell identity during human development, reprogramming and disease using hESC and organoid models.

In this project, some of the specific aims include but are not limited to:

– To use genome editing technologies to perturb the cell cycle-cell identity cross-talk
– To measure cell cycle dynamics during cellular transitions by state-of-the-art live cell imaging
– To integrate sequencing (OMICS) and imaging data sets

The successful candidate will have the opportunity to decide on the exact project(s) they want to undertake during their postdoc time in the lab. Specifics of different projects will be discussed with Dr Silvia Santos. The successful candidate can either choose one of these projects or decide to undertake a new, independent project within the lab’s interests.