Principal Laboratory Research Scientist

We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function. 

We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng. et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration. We model these recurrent human somatic driver mutations using patient derived induced pluripotent stem cells (Rouhani et al. Nature Genetics, 2022), organoids and bio-engineered tissues. We are also developing and applying new technologies in single molecule spatial genomics and in vivo gene editing. 

If you are a senior scientist, this may be an excellent opportunity for you to join the lab. You will be heavily involved in the start-up of a major laboratory and will provide senior level support in broad scientific management for the research group. Alongside providing technical assistance to other lab members, there will be opportunities and strong encouragement for you to lead independent projects in areas such in vivo gene editing and liver epigenetics.