Research Assistant

We are recruiting a Research Assistant to join our world-leading research centre to investigate the role of the DNA damage response (DDR) in Huntington’s disease pathogenesis.

You will examine the involvement of DDR proteins in repeat expansion in patient-derived cell models and will use induced pluripotent stem cells (iPSCs) from patients with HD to study the role of DDR proteins, with a focus on the MutL MMR complexes, in repeat instability. Our HD-iPSC system shows robust CAG repeat expansions in culture, allowing us to dissect the role of DDR genes and variants in mediating repeat instability. You will use cutting-edge techniques including CRISPR based techniques to modulate expression of DDR genes of interest.

The role is available immediately and funded by until 31 August 2026 in the first instance.