Research Assistant / Research Fellow

A research assistant / fellow position is available to join Professor David Long’s kidney development and disease group. The researcher will work on a Diabetes UK funded grant using 3-dimensional organoids to establish an experimental model to understand how vascular complications arise in diabetic patients. To do this, the post-holder will replicate the diabetic environment by providing (i) vascular organoids with an external blood supply to directly deliver glucose to the endothelial vessel lining and (ii) use serum from diabetic patients with and without vascular complications to refine the milieu the vascular organoid is exposed to. Secondly, we will identify molecular changes in the transcriptome of the vascular organoid following exposure to serum obtained from diabetic patients using single-cell technologies to develop targeted therapies for diabetic vascular complications. The salary in this post is either at grade 6B (£37,332 – £39,980 per annum) or grade 7 (£42,099 – £43,205 per annum) and is funded for 30 months in the first instance.