Applications are invited for an enthusiastic and committed post-doctoral scientist to join a vibrant team investigating the cell biology of a group of neurological conditions called hereditary spastic paraplegias. This project is based in the group of Professor Evan Reid at Cambridge Institute for Medical Research and is funded for 3 years. It would be particularly appealing for a cell biologist who is interested in understanding the causes of genetic disease.
The project aims to understand the functions of hereditary spastic paraplegia proteins in the molecular pathogenesis of axonal degeneration. The work will be at the interface between cell biology (especially membrane traffic) and molecular neuroscience, and will begin with functional genomic synthetic lethality screens using human iPSC-derived neuronal models of HSP, before going on to characterize the cell biology of “hits” from the screen.