We are looking for a skilled research associate with a molecular biological background to join a vibrant group investigating amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). You will be using CRISPR to gene edit human stem cells to introduce unpublished disease-linked mutations. This work will entail the use of directed differentiation using genetic cassettes to accelerate progress and facilitate isogenic studies of derived neurons and microglia.
This project is part of a larger collaborative effort funded by ARUK and the Dementia Consortium with extensive bioinformatic support, offering the candidate unique exposure to industry and dry lab science. Our collective aim is to explore uncharted genomic territory and identify novel mechanistic pathways that have not been appreciated by the ALS-FTD field to date.
The candidate will use high-content cellular imaging (Opera Phenix), RNASeq and a variety of other phenotyping approaches to characterise the cells and there will be opportunities to learn neuronal-microglial co-culture techniques.
You will be expected to write your own manuscripts, help with mentoring students who come through the laboratory, and will be encouraged to write grant applications to further your own career in the longer term.