The Rawlins lab studies lung development and lung stem cells with a particular focus on using human organoid models to study cellular and molecular mechanisms controlling development and repair. We have recently developed a series of innovative human lung organoid models and accompanying CRISPR tools which will further enable the study of human lung disease.

This position is part of a Wellcome-funded highly collaborative UK-based project which brings together human geneticists, lung cell biologists and clinicians to define the genetics and cell biology underlying chronic human lung disease. The specific project will focus initially on the use of CRISPR tools to model human genetic variation in organoids. There will be excellent scope for innovation and direction-setting, focusing on the long-term aim of identifying and testing potential disease-modifying pathways.